Facts About Osteoporosis

Prior knowledge about pathophysiology of oesteoporosis is vital in order to avoid and treat osteoporosis or osteopenia effectively. No one can avoid this condition since as one ages his or her bones are prone to fractures and injuries which causes this condition. The frequent process of removal of small amounts of bone minerals commonly referred to as resorption is common to all human beings. On the flipside deposition which refers to the process of restoring the mineral loss, must be enhanced in order to avoid the effects of resorption. The two processes of resorption and deposition must always be kept at per or optimum.

Pathophysiology of osteoporosis sums up the process of resorption and deposition of minerals that make up the bones or it may sometimes be referred to as bone remodeling. These two processes occur concurrently and if one supersedes the other the effects are generally exhibited. For instance, when the resorption is greater than deposition, the bones are bound to weaken and one will be susceptible   to osteopenia. If this condition or process takes along duration, the individual will suffer from this condition whereby the bones become prone to fractures and extreme weakening.

So how can one determine the optimum levels of resorption and deposition? Two cells namely, osteoclasts and osteoblasts are the main determinants of the optimality of these two processes whereby their activities play a major role in bringing about the optimality. These two cells are produced from the blood cell lineage. Besides playing the role of bone strengthening and health enhancement, the balance between the process deposition and reabsorption has an effect on bone growth and loss.

The main functions played by the two cells include; for the osteoclasts, their activation will enhance bone resorption whereby their active ion channels lowers the ph in their microenvironment thereby leading bone dissolution. The reverse role played by osteoblasts involves osteoblast waves form are formed. This will lead to bone formation. The process of bone formation usually takes a longer time as compared to the process of bone loss therefore any increase in remodeling results in net loss of bone.

Osteoporosis is multifactoral both in pathophysiology and etiology and this serves as a key distinctive feature for this condition. Bone fragility and frequent injuries are the main predisposing factors for this condition. The injuries may be due to poor posture that fails to secure bony parts of the body, frequent falling on one side, low flesh content that act act cushion against injury of bones and frequent falling. Fragility of bones is as a result of many factors that include alteration of bone material composition, too low mass density among others.

So what could be the cause of the low bone mass? Inadequate calcium intake, lack of exercises deficiency of gonadol hormone, effects of drugs for treatment of other maladies and inadequacy of vitamin D in the system lower the bone mass. A comprehensive understanding of the pathophysiology of osteoporosis will form the best basis towards the proper treatment of this condition.


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